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Its loss impairs DNA damage checkpoints and apoptotic response, further enabling unchecked division of genomically unstable cells (118120)

Regular screening every 1-2 years catches disease early in high-risk patientswaiting until symptoms appear often means 60-70% of kidney function is already lost

Melanocortin agonists include PT-141 and Melanotan II, while mitochondrial and longevity peptides include MOTS-C and Epithalon